لیست کامل داروهای دوپینگی 2010
THE 2010 PROHIBITED LIST
WORLD ANTI-DOPING CODE
Valid 1 January 2010
All
Prohibited Substances shall be considered as “SpecifiedSubstances” except Substances in classes S1, S2.1 to S2.5,
S.4.4 and S6.a, and
Prohibited Methods M1, M2 and M3.SUBSTANCES AND METHODS PROHIBITED AT ALL TIMES
(IN- AND OUT-OF-COMPETITION)
PROHIBITED SUBSTANCES
S1. ANABOLIC AGENTS
Anabolic agents are prohibited.
1. Anabolic Androgenic Steroids (AAS)
a. Exogenous
* AAS, including:1-androstendiol
(5α-androst-1-ene-3β,17β-diol ); 1-androstendione (5α-androst-1-ene-3,17-dione)
; bolandiol (19-norandrostenediol); bolasterone;boldenone; boldione
(androsta-1,4-diene-3,17-dione); calusterone;clostebol; danazol
(17α-ethynyl-17β-hydroxyandrost-4-eno[2,3-d]isoxazole);dehydrochlormethyltestosterone
(4-chloro-17β-hydroxy-17α-methylandrosta-1,4-dien-3-one)
; desoxymethyltestosterone (17α-methyl-5α-androst-2-en-17
β-ol); drostanolone; ethylestrenol (19-nor-17α-pregn-4-en-17-ol);fluoxymesterone; formebolone; furazabol
(17β-hydroxy-17α-methyl-5α-androstano[2,3-c]-furazan)
; gestrinone; 4-hydroxytestosterone (4,17β-dihydroxyandrost-4-en-3-one)
; mestanolone; mesterolone; metenolone;methandienone
(17β-hydroxy-17α-methylandrosta-1,4-dien-3-one);methandriol; methasterone
(2α, 17α-dimethyl-5α-androstane-3-one-17β-ol);methyldienolone
(17β-hydroxy-17α-methylestra-4,9-dien-3-one); methyl-1-testosterone
(17β-hydroxy-17α-methyl-5α-androst-1-en-3-one);methylnortestosterone
(17β-hydroxy-17α-methylestr-4-en-3-one);methyltestosterone; metribolone
(methyltrienolone, 17β-hydroxy-17α-methylestra-4,9,11-trien-3-one)
; mibolerone; nandrolone; 19-norandrostenedione
(estr-4-ene-3,17-dione); norboletone; norclostebol;norethandrolone; oxabolone; oxandrolone; oxymesterone; oxymetholone;
prostanozol
(17β-hydroxy-5α-androstano[3,2-c] pyrazole); quinbolone;The Prohibited List 2010
19 September 2009
3
stanozolol; stenbolone; 1-testosterone
(17β-hydroxy-5α-androst-1-en-3-one)
; tetrahydrogestrinone (18a-homo-pregna-4,9,11-trien-17β-ol-3-one);trenbolone
and other substances with a similar chemical structure or similarbiological effect(s).
b. Endogenous
** AAS when administered exogenously:androstenediol
(androst-5-ene-3β,17β-diol); androstenedione (androst-4-ene-3,17-dione)
; dihydrotestosterone (17β-hydroxy-5α-androstan-3-one) ;prasterone
(dehydroepiandrosterone, DHEA); testosteroneand the following metabolites and isomers:
5
α-androstane-3α,17α-diol; 5α-androstane-3α,17β-diol; 5α-androstane-3
β,17α-diol; 5α-androstane-3β,17β-diol; androst-4-ene-3α,17α-diol;androst-4-ene-3
α,17β-diol; androst-4-ene-3β,17α-diol; androst-5-ene-3
α,17α-diol; androst-5-ene-3α,17β-diol; androst-5-ene-3β,17α-diol;4-androstenediol
(androst-4-ene-3β,17β-diol); 5-androstenedione (androst-5-ene-3,17-dione)
; epi-dihydrotestosterone; epitestosterone; 3α-hydroxy-5
α-androstan-17-one; 3β-hydroxy-5α-androstan-17-one; 19-norandrosterone; 19-noretiocholanolone.
2.
Other Anabolic Agents, including but not limited to:Clenbuterol, selective androgen receptor modulators (SARMs), tibolone,
zeranol, zilpaterol.
For purposes of this section:
*
“exogenous” refers to a substance which is not ordinarily capable of beingproduced by the body naturally.
**
“endogenous” refers to a substance which is capable of being produced by thebody naturally.
S2. PEPTIDE HORMONES, GROWTH FACTORS AND RELATED
SUBSTANCES
The following substances and their releasing factors are prohibited:
1. Erythropoiesis-Stimulating Agents [
e.g. erythropoietin (EPO),darbepoetin (dEPO), methoxy polyethylene glycol-epoetin beta
(CERA), hematide];
2. Chorionic Gonadotrophin (CG) and Luteinizing Hormone (LH)
inmales;
3. Insulins;
4. Corticotrophins;
The Prohibited List 2010
19 September 2009
4
5. Growth Hormone (GH), Insulin-like Growth Factor-1 (IGF-1),
Mechano Growth Factors (MGFs), Platelet-Derived Growth Factor
(PDGF), Fibroblast Growth Factors (FGFs), Vascular-Endothelial
Growth Factor (VEGF) and Hepatocyte Growth Factor (HGF)
as wellas any other growth factor affecting muscle, tendon or ligament protein
synthesis/degradation, vascularisation, energy utilization, regenerative
capacity or fibre type switching;
6. Platelet-derived preparations (e.g. Platelet Rich Plasma, “blood
spinning”)
administered by intramuscular route. Other routes ofadministration require a declaration of
Use in accordance with theInternational Standard for Therapeutic Use Exemptions.
and other substances with similar chemical structure or similar biological
effect(s).
S3. BETA-2 AGONISTS
All beta-2 agonists (including both optical isomers where relevant) are prohibited
except salbutamol (maximum 1600 micrograms over 24 hours) and salmeterol by
inhalation which require a declaration of
Use in accordance with the InternationalStandard for Therapeutic Use Exemptions.
The presence of salbutamol in urine in excess of 1000 ng/mL is presumed not to
be an intended therapeutic use of the substance and will be considered as an
Adverse Analytical Finding
unless the Athlete proves, through a controlledpharmacokinetic study, that the abnormal result was the consequence of the use
of a therapeutic dose (maximum 1600 micrograms over 24 hours) of inhaled
salbutamol.
S4. HORMONE ANTAGONISTS AND MODULATORS
The following classes are prohibited:
1. Aromatase inhibitors
including, but not limited to: aminoglutethimide,anastrozole, androsta-1,4,6-triene-3,17-dione
(androstatrienedione), 4-androstene-3,6,17 trione (6-oxo),
exemestane, formestane, letrozole, testolactone.
2. Selective estrogen receptor modulators (SERMs)
including, but notlimited to
: raloxifene, tamoxifen, toremifene.3. Other anti-estrogenic substances
including, but not limited to:clomiphene, cyclofenil, fulvestrant.
The Prohibited List 2010
19 September 2009
5
4. Agents modifying myostatin function(s)
including but not limited to:myostatin inhibitors.
S5. DIURETICS AND OTHER MASKING AGENTS
Masking agents are prohibited. They include:
Diuretics, probenecid, plasma expanders (
e.g. glycerol; intravenousadministration of
albumin, dextran, hydroxyethyl starch and mannitol) andother substances with similar biological effect(s).
Diuretics include:
Acetazolamide, amiloride, bumetanide, canrenone, chlorthalidone,
etacrynic acid, furosemide, indapamide, metolazone, spironolactone,
thiazides (
e.g. bendroflumethiazide, chlorothiazide, hydrochlorothiazide),triamterene
, and other substances with a similar chemical structure or similarbiological effect(s) (except drosperinone, pamabrom and topical dorzolamide and
brinzolamide, which are not prohibited).
A Therapeutic Use Exemption for diuretics and masking agents is not valid if an
Athlete
’s urine contains such substance(s) in association with threshold or subthresholdlevels of an exogenous
Prohibited Substance(s).The Prohibited List 2010
19 September 2009
6
PROHIBITED METHODS
M1. ENHANCEMENT OF OXYGEN TRANSFER
The following are prohibited:
1. Blood doping, including the use of autologous, homologous or heterologous
blood or red blood cell products of any origin.
2. Artificially enhancing the uptake, transport or delivery of oxygen, including
but not limited to perfluorochemicals, efaproxiral (RSR13) and modified
haemoglobin products (e.g. haemoglobin-based blood substitutes,
microencapsulated haemoglobin products), excluding supplemental oxygen.
M2. CHEMICAL AND PHYSICAL MANIPULATION
1.
Tampering, or attempting to tamper, in order to alter the integrity andvalidity of
Samples collected during Doping Controls is prohibited. Theseinclude but are not limited to catheterisation, urine substitution and/or
adulteration (e.g. proteases).
2. Intravenous infusions are prohibited except for those legitimately received in
the course of hospital admissions or clinical investigations.
M3. GENE DOPING
The following
, with the potential to enhance athletic performance, are prohibited:1- The transfer of cells or genetic elements (e.g. DNA, RNA);
2- The use of pharmacological or biological agents that alter gene expression
.Peroxisome Proliferator Activated Receptor
δ (PPARδ) agonists (e.g. GW 1516)and PPAR
δ-AMP-activated protein kinase (AMPK) axis agonists (e.g. AICAR) areprohibited.
The Prohibited List 2010
19 September 2009
7
SUBSTANCES AND METHODS
PROHIBITED IN-COMPETITION
In addition to the categories S1 to S5 and M1 to M3 defined above,
the following categories are prohibited in competition:
PROHIBITED SUBSTANCES
S6. STIMULANTS
All stimulants (including both optical isomers where relevant) are prohibited,
except imidazole derivatives for topical use and those stimulants included in the
2010 Monitoring Program
*.Stimulants include:
a: Non-Specified Stimulants:
Adrafinil; amfepramone; amiphenazole; amphetamine; amphetaminil;
benfluorex; benzphetamine; benzylpiperazine; bromantan; clobenzorex;
cocaine; cropropamide; crotetamide; dimethylamphetamine;
etilamphetamine; famprofazone; fencamine; fenetylline; fenfluramine;
fenproporex; furfenorex; mefenorex; mephentermine; mesocarb;
methamphetamine(
d-); p-methylamphetamine;methylenedioxyamphetamine; methylenedioxymethamphetamine;
methylhexaneamine (dimethylpentylamine); modafinil; norfenfluramine;
phendimetrazine; phenmetrazine; phentermine; 4-phenylpiracetam
(carphedon); prenylamine; prolintane.
A stimulant not expressly listed in this section is a Specified Substance.
b: Specified Stimulants (examples):
Adrenaline
**; cathine***; ephedrine****; etamivan; etilefrine; fenbutrazate;fencamfamin; heptaminol; isometheptene; levmetamphetamine;
meclofenoxate; methylephedrine
****; methylphenidate; nikethamide;norfenefrine; octopamine; oxilofrine; parahydroxyamphetamine;
pemoline; pentetrazol; phenpromethamine; propylhexedrine;
pseudoephedrine
*****; selegiline; sibutramine; strychnine;tuaminoheptane
and other substances with a similar chemical structure orsimilar biological effect(s).
The Prohibited List 2010
19 September 2009
8
*
The following substances included in the 2010 Monitoring Program (bupropion,caffeine, phenylephrine, phenylpropanolamine, pipradol, synephrine) are not
considered as
Prohibited Substances.**
Adrenaline associated with local anaesthetic agents or by local administration(e.g. nasal, ophthalmologic) is not prohibited.
***
Cathine is prohibited when its concentration in urine is greater than 5micrograms per milliliter.
****
Each of ephedrine and methylephedrine is prohibited when itsconcentration in urine is greater than 10 micrograms per milliliter.
*****
Pseudoephedrine is prohibited when its concentration in urine is greaterthan 150 micrograms per milliliter.
S7. NARCOTICS
The following narcotics are prohibited:
Buprenorphine, dextromoramide, diamorphine (heroin), fentanyl and its
derivatives, hydromorphone, methadone, morphine, oxycodone,
oxymorphone, pentazocine, pethidine.
S8. CANNABINOIDS
Natural or synthetic
Δ9-tetrahydrocannabinol (THC) and THC-like cannabinoids(e.g. hashish, marijuana, HU-210) are prohibited.
S9. GLUCOCORTICOSTEROIDS
All glucocorticosteroids are prohibited when administered by oral, intravenous,
intramuscular or rectal routes.
In accordance with the International Standard for Therapeutic Use Exemptions, a
declaration of
Use must be completed by the Athlete for glucocorticosteroidsadministered by intraarticular, periarticular, peritendinous, epidural, intradermal
and inhalation routes, except as noted below.
Topical preparations when used for auricular, buccal, dermatological (including
iontophoresis/phonophoresis), gingival, nasal, ophthalmic and perianal disorders
are not prohibited and require neither a Therapeutic Use Exemption nor a
declaration of
Use.The Prohibited List 2010
19 September 2009
9
SUBSTANCES PROHIBITED IN PARTICULAR
SPORTS
P1. ALCOHOL
Alcohol (ethanol) is prohibited
In-Competition only, in the following sports.Detection will be conducted by analysis of breath and/or blood. The doping
violation threshold (haematological values) is 0.10 g/L.
Aeronautic (FAI)
Archery (FITA)
Automobile (FIA)
Karate (WKF)
Modern Pentathlon (UIPM) fordisciplines involving shooting
Motorcycling (FIM)
Ninepin and Tenpin Bowling (FIQ)
Powerboating (UIM)P2. BETA-BLOCKERS
Unless otherwise specified, beta-blockers are prohibited
In-Competition only, inthe following sports.
Aeronautic (FAI)
Archery (FITA) (also prohibitedOut-of-Competition
)
Automobile (FIA)
Billiards and Snooker (WCBS)
Bobsleigh (FIBT)
Boules (CMSB)
Bridge (FMB)
Curling (WCF)
Golf (IGF)
Gymnastics (FIG)
Motorcycling (FIM)
Modern Pentathlon (UIPM) fordisciplines involving shooting
Ninepin and Tenpin Bowling (FIQ)
Powerboating (UIM)
Sailing (ISAF) for match racehelms only
Shooting (ISSF, IPC) (alsoprohibited
Out-of-Competition)
Skiing/Snowboarding (FIS) in skijumping, freestyle aerials/halfpipe
and snowboard halfpipe/big air
Wrestling (FILA)Beta-blockers include, but are not limited to, the following:
Acebutolol, alprenolol, atenolol, betaxolol, bisoprolol, bunolol, carteolol,
carvedilol, celiprolol, esmolol, labetalol, levobunolol, metipranolol,
metoprolol, nadolol, oxprenolol, pindolol, propranolol, sotalol, timolol
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